Which adverse effect is classically associated with thioridazine?

Which adverse effect is classically associated with thioridazine?

• A. Retinal Pigmentation
• B. Tardive Dyskinesia
• C. Hyperprolactinemia
• D. Weight Gain

Answer: (A)

Retinal pigmentation is the classic adverse effect associated with thioridazine. Thioridazine is a low-potency phenothiazine antipsychotic, and it can cause dose- and duration-dependent pigmentary changes in the retina that may lead to vision problems, sometimes irreversibly. This ocular toxicity is a distinctive and well-known risk for thioridazine, setting it apart from many other antipsychotics. Tardive dyskinesia is more generally linked to long-term D2 blockade across many typical antipsychotics, especially high-potency ones. Hyperprolactinemia arises from dopaminergic blockade in the tuberoinfundibular pathway and is common with several antipsychotics, particularly potent D2 antagonists. Weight gain is more associated with certain atypical antipsychotics and some low-potency drugs, but it’s not the hallmark adverse effect for thioridazine.

Retinal pigmentation is the classic adverse effect associated with thioridazine. Thioridazine is a low-potency phenothiazine antipsychotic, and it can cause dose- and duration-dependent pigmentary changes in the retina that may lead to vision problems, sometimes irreversibly. This ocular toxicity is a distinctive and well-known risk for thioridazine, setting it apart from many other antipsychotics.

Tardive dyskinesia is more generally linked to long-term D2 blockade across many typical antipsychotics, especially high-potency ones. Hyperprolactinemia arises from dopaminergic blockade in the tuberoinfundibular pathway and is common with several antipsychotics, particularly potent D2 antagonists. Weight gain is more associated with certain atypical antipsychotics and some low-potency drugs, but it’s not the hallmark adverse effect for thioridazine.